How connection and support can strengthen your immune system, new study finds
By
Aubrey Razon
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As we age, maintaining a strong immune system becomes more crucial than ever. At The GrayVine, we believe that health is shaped by everyday habits, not just occasional efforts.
Could a surprising daily habit be the key to boosting your immune system, as revealed by a recent study?
If you've been postponing that catch-up coffee with an old friend or skipping out on community events, it's time to rethink your social calendar.
According to a study published in the January 2025 issue of Nature Human Behaviour, there's a profound link between our social interactions and our physical health.
The research, conducted by the University of Cambridge in the UK and Fudan University in China, suggests that our social habits could be doing more than just filling our hearts with joy—they could be adding years to our lives and fortifying our immune systems.

In the United States, loneliness and social isolation are not just buzzwords; they're a public health concern.
Approximately one in three adults reports feeling lonely, and about one in four lacks emotional and social support.
These conditions are not merely emotional states; they have tangible effects on our health.
Loneliness and social isolation have been linked to an increased risk of heart disease, stroke, type 2 diabetes, depression, anxiety, and even premature death.
It's crucial to distinguish between social isolation—an objective measure of how much contact a person has with others—and loneliness, a subjective feeling of being alone regardless of the amount of social contact.
You can be in a room full of people and still feel lonely if you lack meaningful connections.
The study in question analyzed data from 42,062 participants, with an average age of 54, from the UK Biobank—a comprehensive biomedical database.
Over an average follow-up of 14 years, researchers examined the participants' proteomic data (the set of proteins found in their blood) alongside their reported levels of social isolation and loneliness.
The results were eye-opening: 175 proteins were associated with social isolation, and 26 with loneliness, with an 85% overlap between the two.
Many of these proteins are part of our immune response, which can trigger inflammation when fighting off illness.
Chronic inflammation is a known culprit behind many diseases, including heart disease and type 2 diabetes.
Specific proteins stood out in the study.
For instance, ADM, a protein that helps regulate stress responses and the hormone oxytocin (associated with feelings of love and attachment), was found at higher levels in lonely individuals.
This suggests that loneliness may trigger an immune response as if the body were fighting an infection.
Moreover, higher ADM levels were linked to changes in brain regions responsible for emotions, cognition, and social processes.
This study provides a biological explanation for the long-observed link between social well-being and physical health.
It underscores the importance of staying connected with others for our physical and mental health.
So, what can you do to combat loneliness and social isolation? Here are some actionable tips:
1. Volunteer
Engaging in charity work can expand your social network and provide a sense of purpose and fulfillment.
2. Join a Club or Team
Participating in group sports, walking clubs, or book clubs can improve your mood and cognitive function while providing social interaction.
3. Learn Something New
Taking classes in cooking, art, or any other hobby can help you meet like-minded individuals and keep your brain sharp.
4. Reach Out
Make that phone call, invite a neighbor over for a meal, or offer to help someone in need. Small gestures can make a big difference.
5. Be Authentic
Deepen your connections by being genuine and open with others, building trust and rapport over time.
The evidence is clear: social engagement is not just a source of happiness but a vital component of our health.
If you've been feeling lonely or avoiding social opportunities, it's time to take proactive steps.
Find activities that you enjoy and make it a goal to forge new friendships.
Providing and receiving social support can lead to a happier, more fulfilling life, and as this study shows, a healthier one too.
At The GrayVine, we believe in the power of community and connection. Have you found unique ways to stay socially active?
Share your experiences with us in the comments below. Let's inspire each other to keep our social lives—and our immune systems—thriving.
Could a surprising daily habit be the key to boosting your immune system, as revealed by a recent study?
If you've been postponing that catch-up coffee with an old friend or skipping out on community events, it's time to rethink your social calendar.
According to a study published in the January 2025 issue of Nature Human Behaviour, there's a profound link between our social interactions and our physical health.
The research, conducted by the University of Cambridge in the UK and Fudan University in China, suggests that our social habits could be doing more than just filling our hearts with joy—they could be adding years to our lives and fortifying our immune systems.

Loneliness and social isolation can harm health by increasing the risk of various diseases and reducing life expectancy. Image souce: ANTONI SHKRABA production/Pexels.
In the United States, loneliness and social isolation are not just buzzwords; they're a public health concern.
Approximately one in three adults reports feeling lonely, and about one in four lacks emotional and social support.
These conditions are not merely emotional states; they have tangible effects on our health.
Loneliness and social isolation have been linked to an increased risk of heart disease, stroke, type 2 diabetes, depression, anxiety, and even premature death.
It's crucial to distinguish between social isolation—an objective measure of how much contact a person has with others—and loneliness, a subjective feeling of being alone regardless of the amount of social contact.
You can be in a room full of people and still feel lonely if you lack meaningful connections.
The study in question analyzed data from 42,062 participants, with an average age of 54, from the UK Biobank—a comprehensive biomedical database.
Over an average follow-up of 14 years, researchers examined the participants' proteomic data (the set of proteins found in their blood) alongside their reported levels of social isolation and loneliness.
The results were eye-opening: 175 proteins were associated with social isolation, and 26 with loneliness, with an 85% overlap between the two.
Many of these proteins are part of our immune response, which can trigger inflammation when fighting off illness.
Chronic inflammation is a known culprit behind many diseases, including heart disease and type 2 diabetes.
Specific proteins stood out in the study.
For instance, ADM, a protein that helps regulate stress responses and the hormone oxytocin (associated with feelings of love and attachment), was found at higher levels in lonely individuals.
This suggests that loneliness may trigger an immune response as if the body were fighting an infection.
Moreover, higher ADM levels were linked to changes in brain regions responsible for emotions, cognition, and social processes.
This study provides a biological explanation for the long-observed link between social well-being and physical health.
It underscores the importance of staying connected with others for our physical and mental health.
So, what can you do to combat loneliness and social isolation? Here are some actionable tips:
1. Volunteer
Engaging in charity work can expand your social network and provide a sense of purpose and fulfillment.
2. Join a Club or Team
Participating in group sports, walking clubs, or book clubs can improve your mood and cognitive function while providing social interaction.
3. Learn Something New
Taking classes in cooking, art, or any other hobby can help you meet like-minded individuals and keep your brain sharp.
4. Reach Out
Make that phone call, invite a neighbor over for a meal, or offer to help someone in need. Small gestures can make a big difference.
5. Be Authentic
Deepen your connections by being genuine and open with others, building trust and rapport over time.
The evidence is clear: social engagement is not just a source of happiness but a vital component of our health.
If you've been feeling lonely or avoiding social opportunities, it's time to take proactive steps.
Find activities that you enjoy and make it a goal to forge new friendships.
Providing and receiving social support can lead to a happier, more fulfilling life, and as this study shows, a healthier one too.
Key Takeaways
- Social habits such as meeting with family and friends may improve health and possibly extend lifespan.
- Loneliness and social isolation can negatively impact health, increasing the risk of various diseases and earlier mortality.
- Researchers found that certain proteins associated with social isolation and loneliness may play a role in inflammation and chronic disease.
- Taking steps to prevent loneliness, such as engaging in social activities and connecting with others, can be beneficial for both mental and physical health.
Share your experiences with us in the comments below. Let's inspire each other to keep our social lives—and our immune systems—thriving.