Iron deficiency without anemia: is it possible?
By
Aubrey Razon
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Iron isn’t just about strength—it’s a hidden force powering your body’s every move. When its levels drop, the effects can be subtle but significant.
Could your health be missing this essential mineral without you even realizing it?
Iron deficiency and iron deficiency anemia might sound like two acts of the same play, but there's a crucial scene change between them.
You can be iron deficient without the plot twist of anemia, and here's why that's a big deal.
Iron is the star of the show when it comes to oxygen transport in the blood, energy production, and protein synthesis.

It's a key player in your red blood cells, bone marrow, muscles, and even the brain. When your body's iron stores start to dip, it's like the stage lights dimming slowly—you might not notice at first, but the performance is definitely affected.
Dr. Casey O’Connell, a hematologist and an associate professor of Clinical Medicine, shines a spotlight on this issue.
“Iron deficiency anemia is just a later stage of iron deficiency,” she explains.
Your body, being the resourceful director it is, will first use up the iron stored backstage before it affects the red blood cell count.
Once those stores are depleted, you're in the final act of iron deficiency anemia, where the red blood cell count drops and the show can't go on.
Catching iron deficiency before it gets a standing ovation as anemia is crucial.
Dr. Annette von Drygalski, a hematologist, warns that undiagnosed iron deficiency can lead to poor heart function and, in women, serious complications during pregnancy, including mortality, lower birth rates, and potential developmental issues in children.
A complete blood count (CBC) test is like the dress rehearsal before opening night—it's essential for diagnosing anemia.
It measures the red blood cell count (RBC), hemoglobin (HGV), and hematocrit (HCT), which are like the cast members of your blood's production.
To confirm iron deficiency as the cause of anemia, doctors will compare the CBC with a ferritin test and a full iron panel.
Ferritin, the understudy for iron stores in your body, is a key biomarker.
However, the medical community is still debating over what the threshold for low ferritin should be.
The World Health Organization sets the bar at below 15 nanograms per milliliter, but some doctors diagnose iron deficiency when ferritin falls below 30 nanograms per milliliter.
In a recent plot twist, the American Society of Hematology announced plans to revise the guidelines for diagnosing iron deficiency, including the ferritin threshold.
Ferritin levels are undoubtedly important, but they're not the sole indicator of iron deficiency.
Dr. Danielle Nance, a hematologist, emphasizes that healthcare providers must consider the whole health picture of a patient.
It's the difference between a one-hit-wonder and a timeless classic when it comes to diagnosis.
So, what's your next move?
If you're feeling fatigued, weak, or just not up to your usual encore-worthy performance, it might be time to check your iron levels.
Talk to your doctor about getting a CBC and ferritin test to ensure your body's show goes on without a hitch.
Have you or someone you know been affected by iron deficiency? What steps did you take to address it? Share your experiences and tips in the comments below.
Could your health be missing this essential mineral without you even realizing it?
Iron deficiency and iron deficiency anemia might sound like two acts of the same play, but there's a crucial scene change between them.
You can be iron deficient without the plot twist of anemia, and here's why that's a big deal.
Iron is the star of the show when it comes to oxygen transport in the blood, energy production, and protein synthesis.

Catching iron deficiency early is crucial to prevent more serious health problems. Image source: Mikael Blomkvist/Pexels.
It's a key player in your red blood cells, bone marrow, muscles, and even the brain. When your body's iron stores start to dip, it's like the stage lights dimming slowly—you might not notice at first, but the performance is definitely affected.
Dr. Casey O’Connell, a hematologist and an associate professor of Clinical Medicine, shines a spotlight on this issue.
“Iron deficiency anemia is just a later stage of iron deficiency,” she explains.
Your body, being the resourceful director it is, will first use up the iron stored backstage before it affects the red blood cell count.
Once those stores are depleted, you're in the final act of iron deficiency anemia, where the red blood cell count drops and the show can't go on.
Catching iron deficiency before it gets a standing ovation as anemia is crucial.
Dr. Annette von Drygalski, a hematologist, warns that undiagnosed iron deficiency can lead to poor heart function and, in women, serious complications during pregnancy, including mortality, lower birth rates, and potential developmental issues in children.
A complete blood count (CBC) test is like the dress rehearsal before opening night—it's essential for diagnosing anemia.
It measures the red blood cell count (RBC), hemoglobin (HGV), and hematocrit (HCT), which are like the cast members of your blood's production.
To confirm iron deficiency as the cause of anemia, doctors will compare the CBC with a ferritin test and a full iron panel.
Ferritin, the understudy for iron stores in your body, is a key biomarker.
However, the medical community is still debating over what the threshold for low ferritin should be.
The World Health Organization sets the bar at below 15 nanograms per milliliter, but some doctors diagnose iron deficiency when ferritin falls below 30 nanograms per milliliter.
In a recent plot twist, the American Society of Hematology announced plans to revise the guidelines for diagnosing iron deficiency, including the ferritin threshold.
Ferritin levels are undoubtedly important, but they're not the sole indicator of iron deficiency.
Dr. Danielle Nance, a hematologist, emphasizes that healthcare providers must consider the whole health picture of a patient.
It's the difference between a one-hit-wonder and a timeless classic when it comes to diagnosis.
So, what's your next move?
If you're feeling fatigued, weak, or just not up to your usual encore-worthy performance, it might be time to check your iron levels.
Talk to your doctor about getting a CBC and ferritin test to ensure your body's show goes on without a hitch.
Key Takeaways
- One can experience iron deficiency without having iron deficiency anemia, which is a later stage of iron deficiency.
- Catching iron deficiency early is crucial to prevent more serious health problems, including poor heart function and complications during pregnancy.
- A complete blood count (CBC) test, along with a ferretin test and a full iron panel, aids in the diagnosis of iron deficiency.
- There is some disagreement in the medical community about the ferretin level threshold for diagnosing iron deficiency, with different organisations suggesting varying numbers.